Hen Party Let Down

I'm so sorry - it really hurts when such a long standing friend changes like this.

It may be that the relationship has run its course - or it may be that there is something going on in her life that she doesn't want to talk about, so she is using work as an excuse for avoiding you.

Other than missing your wedding and hen do, is she in touch? If you are hearing from her at other times, then it suggests she has genuine reasons for not coming. If she is not in touch at all, then it would be more of an indication the friendship is over.

The only other thing to consider - you mention she has a new boyfriend. Has the change in her behaviour been since he turned up? If it is, you might want to monitor the situation in case the new guy is trying to cut her off from her friends - I know that's unusual, but it does happen.

I agree with romantic green, it really depends on whether she's still in communication with you when you most need her and there may be reasons why it appears she's prioritising her relationship over your friendship.
I had something similar happen to me, I was going through a lot of stuff with my grandparents who were terminally ill and didnt disclose this to my friend. I was in a new relationship which required my attention which had to be pulled from all aspects in my life. My friend, despite me being there for the big stuff, evidently felt neglected and blocked me in every way possible without a single word. I felt this betrayed the relationship as she couldn't even discuss it with me. My point is talk to her and tell her how you feel, it's awful having a friendship end prematurely with no closure. It still makes me really sad.